Nothing about diagnosing cancer is simple. Such a life-changing diagnosis requires oncologists to have confidence that their genetic tests are considered the most relevant, up-to-date to guide their diagnostic and treatment decisions.

To get a full picture of highly rearranged cancer genomes in heterogeneous samples, long-range information at high coverage and analysis tools with low false positives and high sensitivities are needed.

Our optical genome mapping collects up to 1600x coverage of genomes to uncover large structural variations beyond what long and short read sequencing can see, at variant allele fractions as low as 1%.

WHY GENOME TESTING?

OUR TOOLS AND PLATFORMS PROVIDE UNPARALLELED STRUCTURAL VARIATION DETECTION FOR CANCER RESEARCH.

Cancer samples are simply too complex for low coverage whole genome sequencing. Tumour heterogeneity, complex rearrangements, and unsequenceable repetitive regions of the Genome create additional difficulties for long and short read sequencing technologies.

Bionano Saphyr Genome Imaging Instrument finds structural variations larger than 500 bp, genome-wide and unbiased and with the highest sensitivities and the lowest false positive rates, down to 1% variant allele fraction.

Our tools and platforms provide unparalleled structural variation detection for cancer research.

Genome testing for Oncology allows you to:

  • See variants in GC rich regions
  • Identify mutations without complex pipelines
  • Stratify samples easily
  • Identify rare and new fusions of known genes
  • Elucidate complex ecDNA structures

WE OFFER ONE OF THE BROADEST ONCOLOGY GENETIC TESTINGS

We provide a wide range of panels for the following cancers:

  • Breast cancer
  • Ovarian cancer
  • Colon cancer
  • Thyroid cancer
  • Prostate cancer
  • Pancreatic cancer
  • Melanoma
  • Sarcoma
  • Kidney cancer
  • Stomach cancer

THE INDALO BIO DIFFERENCE

Indalo Bio offers services to empower Oncologists with expert-curated data to intelligently navigate the biological characteristics of genetic alterations and their clinical relevance in regards to a patient’s tumour profile. Capable of interpreting any alteration in any cancer type, our data helps deliver personalized, evidence-based treatment recommendations for an expanding menu of tests in a fraction of the time.

HOW INDALO BIO TECHNOLOGY WORKS

The Bionano Genome Imaging workflow starts with megabase size DNA isolation. A single enzymatic reaction labels the Genome at a sequence motif which occurs approximately 15 times per 100 kbp in the Genome.

The labelled DNA molecules are linearized in nanochannel arrays on a chip® and imaged in an extremely high throughput, the automated manner by a Genome Imaging Instrument.

Using pairwise alignments, the molecules are structured into local maps or whole-genome de novo assemblies. Spacing of the labels or changes in patterning is detected automatically, Genome-wide, to call all structural variants.

Find Out More

RELATED MATERIALS

Next generation cytogenetics: genome-imaging enables comprehensive structural variant detection for 100 constitutional chromosomal aberrations in 85 samples

Mantere T et al, 2020

Haplotype-resolved diverse human genomes and integrated analysis of structural variation

Ebert P. et al, 2021

Characterization of an unbalanced translocation causing 3q28qter duplication and 10q26.2qter deletion in a patient with global developmental delay and self-injury

Osei-Owusu I. et al, 2020

Hybrid sequencing resolves two germline ultra-complex chromosomal rearrangements consisting of 137 breakpoint junctions in a single carrier

Eisfeldt J. et al, 2020

Towards improved genetic diagnosis of human differences of sex development

Delot E et al, 2021

Towards a Comprehensive Variation Benchmark for Challenging Medically-Relevant Autosomal Genes

Wagner J et al, 2021

New technologies to uncover the molecular basis of disorders of sex development

Barseghyan H et al, 2018

Exploring the Missing Heritability in Subjects With Hearing Loss, Enlarged Vestibular Aqueducts, and A Single or No Pathogenic SLC26A4 Variant

Smits J et al, 2021

Identification of a likely pathogenic structural variation in the LAMA1 gene by Bionano optical mapping

Chen M et al, 2020

Beginner’s Guide to Optical Genome Mapping: The Key to Structural Variation Detection

Dr. Sven Bocklandt

Texas Genetics Society Meeting – 2021

VP Scientific Affairs, Bionano Genomics

Advanced Structural Analysis of Risk Loci for Congenital Diaphragmatic Hernia Using Optical Genome Mapping Technology

Frances High Webinar

Bionano Genome Imaging: Unbiased, Genome-wide Structural Variation Detection in Genetic Disease and Cancer, Down to 1% Allele Fraction

Dr. Sven Bocklandt

From Data to Discovery: Tools to identify the pathogenic structural variant in patients with genetic disease

Dr. Hayk Barseghyan

Resolving Complex Haplotypes Implicated in Alzheimer’s and Other Neurodegenerative Diseases

Dr. Mark T. W. Ebbert

From Data to Discovery: Tools to identify the pathogenic structural variant in patients with genetic disease

Dr. Hayk Barseghyan July 29, 2020

Resolving Complex Haplotypes Implicated in Alzheimer’s and Other Neurodegenerative Diseases

Dr. Mark T. W. Ebbert August 26, 2020 | 8:00A PDT | 11:00A EDT | 5:00P CET

Optical Mapping in Rare Genetic Disease Diagnosis

Pui-Yan Kwok, MD, PhD, Professor October 23, 2020

Bionano Genome Imaging: Unbiased, Genome-wide Structural Variation Detection in Genetic Disease and Cancer, Down to 1% Allele Fraction

Dr. Sven Bocklandt April 21, 2020

Known Unknowns: Unraveling genomic inversions and their role in disease traits

Christopher M. Grochowski December 10, 2020

HOW TO GET STARTED

STEP 1

Contact Us or Book Your Slot Online

STEP 2

Provide Us with Your Sample

STEP 3

Samples are Returned